- 尖閣諸島の領有権についての日本の基本見解
accordingly, the senkaku islands are not included in the territory which japan renounced under article ii of the san francisco peace treaty. the senkaku islands have been placed under the administration of the united states of america as part of the nansei shoto islands, in accordance with article iii of the said treaty, and are included in the area, the administrative rights over which were reverted to japan in accordance with the agreement between japan and the united states of america concerning the ryukyu islands and the daito islands signed on 17 june 1971. the facts outlined herein clearly indicate the status of the senkaku islands being part of the territory of japan.
- 今日は、伊藤博文暗殺記念日
[from waterfalls to ancient capitals - jilin parades its top beauty spots]
gaogouli relics &culture
(china daily)
2009-10-22
- ミエリンに発現しRNA編集を受けるカリウムチャンネルのKv1.1はFOXP2の下流で言語発達に関係する？
a-to-i rna editing modifies a variety of biologically important mrnas, and is specifically catalyzed by either adenosine deaminase acting on rna type 1 (adar1) or type 2 (adar2) in mammals including human. recently several novel a-to-i editing sites were identified in mrnas abundantly expressed in mammalian organs by means of computational genomic analysis, but which enzyme catalyzes these editing sites has not been determined. using rna interference (rnai) knockdowns, we found that cytoplasmic fragile x mental retardation protein interacting protein 2 (cyfip2) mrna had an adar2-mediated editing position and bladder cancer associated protein (blcap) mrna had an adar1-mediated editing position. in addition, we found that adar2 forms a complex with mrnas with adar2-mediated editing positions including glur2, kv1.1 and cyfip2 mrnas, particularly when the editing sites were edited in human cerebellum by means of immunoprecipitation (ip) method. cyfip2 mrna was ubiquitously expressed in human tissues with variable extents of k/e site editing. because adar2 underactivity may be a causative molecular change of death of motor neurons in sporadic amyotrophic lateral sclerosis (als), this newly identified adar2-mediated editing position may become a useful tool for als research.
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